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Zithromax (Azithromycin) is a semi-synthetic antibiotic, effective against a wide variety of bacteria organisms.



DESCRIPTION
Azithromycin tablets belong to a class of medications called macrolide antibiotics. It is used to treat a wide range of infections caused by bacteria, including streptococcal infections of the ear, lungs, skin, and sinuses, and gonococcal and chlamydial infections. It works by stopping bacterial growth.


ORIGINAL USES (ON-LABEL)
Various bacterial infections.

NEWLY DISCOVERED USES (OFF-LABEL)
Chlamydia, diarrhea, drug-induced gingival enlargement, prevention of bacterial endocarditis.

POTENTIAL SIDE EFFECTS
Diarrhea, nausea, rash, abdominal pain, cramping, vomiting.


CAUTIONS

• Use caution if you have liver dysfunction (symptoms of liver problems may include jaundice, malaise, nausea, vomiting, abdominal colic, and fever). Discontinue use if liver dysfunction occurs.
  
• Use caution if you have developed a certain type of abnormal heart rhythm called QT prolongation prior to therapy.
  
• Safety and efficacy of this drug has not been established in children less than six months of age with acute bacterial infections of the ear, sinus or community-acquired pneumonia, or in children less than two years with tonsillitis.
  

DRUG INTERACTIONS
Pimozide, tacrolimus, phenytoin, ergot alkaloids, alfentanil, bromocriptine, tegretol, cyclosporine, digoxin, disopyramide, triazolam, nelfinavir, antacids containing aluminum or magnesium. Consult your pharmacist or physician before starting any new therapy.
[*]
FOOD INTERACTIONS
The suspension formulation, but not the tablet form, has increased absorption (46%) with food.

HERBAL INTERACTIONS
Unknown

PREGNANCY AND BREAST-FEEDING CAUTIONS
FDA Pregnancy Risk Category B. Azithromycin is excreted in the breast milk and may accumulate. Use with caution during breast-feeding.


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