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Vitamin A: Because of the relationship of Accutane to vitamin A, patients should be advised against taking vitamin supplements containing vitamin A to avoid additive toxic effects.
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Accutane may cause serious stomach and intestinal problems. Accutane has been linked to inflammatory bowel disease, which causes inflammation and ulceration of the digestive tract, including the stomach, mouth, and intestines. IBD can affect the large intestine alone, a condition called ulcerative colitis, or any other part of the digestive tract, which is then called Crohn's disease. Symptoms that may indicate the development of IBD or damage to internal organs of patients, may include severe stomach, chest or bowel pain, troubled or painful swallowing, heartburn, fever, weight loss, yellowing of skin or eyes, rectal bleeding, diarrhea, and dark urine. Accutane has been linked to IBD, even in patients who have no previous history of stomach or intestinal problems prior to taking Accutane. IBD is a very serious condition, as even stopping the use of Accutane may not put an end to the effects of the disorder and severe IBD cases may need ongoing treatment or even surgery to remove the affected colon, in order to deal with the symptoms.